Clinical Study Random Whole Body Vibration over 5 Weeks Leads to Effects Similar to Placebo: A Controlled Study in Parkinson’s Disease

Background. Random whole body vibration (WBV) training leads to beneficial short-term effects in patients with Parkinson’s disease (PD). However, the effect ofWBV lasting several weeks is not clear.Objectives. The aim of this study was to assess a random WBV training over 5 weeks in PD.Methods. Twenty-one participants with PDwere allocated to either an experimental or a placebo group matched by age, gender, and Hoehn&Yahr stage. The WBV training consisted of 5 series, 60 s each. In the placebo group, vibration was simulated.The primary outcome was the change of performance in Functional reach test (FRT), step-walk-turn task, biomechanical Gait Analysis, Timed up and go test (TUG), and one leg stance. Findings. In most of the parameters, there was no significant interaction of “time∗group.” Both groups improved significantly in Gait parameters, TUG, and one leg stance. Only in the FRT [F(1, 15) = 8.397; P < 0.05] and in the TUG [F(1, 15) = 4.971; P < 0.05] the experimental group performed significantly better than the placebo group.Conclusions. RandomWBV training over 5 weeks seems to be less effective than reported in previous studies performing short-term training. The slight improvements in the FRT and TUG are not clinically relevant.